The Mendoza wine region is considered the heart of the winemaking industry in Argentina. Located in the eastern foothills of the Andes vineyards are planted at the some of the highest altitudes in the world. The city of Mendoza is the place to base yourself if you plan to tour the vineyards. The city’s wide range of tour operators also makes it a great place to organize rafting, skiing and other adventures in the nearby Andes.